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Narcolepsy-cataplexy
7 OMIM references -
8 associated genes
10 signs/symptoms
PROTEIN INTERACTIONS: 1
Hereditary cerebral hemorrhage with amyloidosis, Dutch type
1 OMIM reference -
1 associated gene
8 signs/symptoms
Narcolepsy-cataplexy
Hereditary cerebral hemorrhage with amyloidosis, Dutch type

CTSH
(UniProt - OMIM)
 APP
(UniProt - OMIM)
HCRT
(UniProt - OMIM)
HLA-DQB1
(UniProt - OMIM)
HLA-DRB1
(UniProt - OMIM)
MOG
(UniProt - OMIM)
P2RY11
(UniProt - OMIM)
TNFSF4
(UniProt - OMIM)
ZNF365
(UniProt - OMIM)

INTERACTOME
ASSOCIATIONS
(click on a score value to see the evidence)
ZNF365
(0.56)
APP


Citations in the biomedical literature:


Narcolepsy-cataplexy
CTSH HCRT HLA-DQB1 HLA-DRB1 MOG P2RY11
TNFSF4 ZNF365
Hereditary cerebral hemorrhage with amyloidosis, Dutch type
APP



Narcolepsy-cataplexy
Hereditary cerebral hemorrhage with amyloidosis, Dutch type

Synonym(s):
- Gélineau disease
Synonym(s):
- HCHWA, Dutch type
- HCHWA-D
Classification (Orphanet):
- Rare neurologic disease
Classification (Orphanet):
- Rare genetic disease
- Rare neurologic disease
- Rare systemic or rheumatologic disease
Classification (ICD10):
- Diseases of the nervous system -
Classification (ICD10):
(no data available)
Epidemiological data:
Class of prevalence: 1-5 / 10 000
Average age onset: adolescence / young
Average age of death: normal
Type of inheritance: unknown
Epidemiological data:
Class of prevalence: <1 / 1 000 000
Average age onset: adulthood
Average age of death: adult
Type of inheritance: autosomal dominant
External references:
7 OMIM references -
1 MeSH reference: D009290
External references:
1 OMIM reference -
2 MeSH references: C537944 / D028243
Narcolepsy-cataplexy
Hereditary cerebral hemorrhage with amyloidosis, Dutch type

Very frequent
- Delirium / hallucination
- Muscle weakness / flaccidity
- Sleep and vigilance disorders
- Somnolence / hypersomnia / parasomnia
- Troubles of memory / amnesia / hypermnesia

Frequent
- Abnormal eye movements / oculomotor disorder
- Anomalies of eyes and vision

Occasional
- Collapse / sudden death / cardiac arrest / cardiorespiratory arrest
- Generalized obesity
- Speech troubles / aphasia / dysphasia / echolalia / mutism / logorrhea / dysprosodia


Very frequent
- Facial pain / cephalalgia / migraine
- Intracranial / cerebral / meningeal hemorrhage
- Psychic / behavioural troubles
- Psychic / psychomotor regression / dementia / intellectual decline

Frequent
- Intracranial / cerebral calcifications
- Seizures / epilepsy / absences / spasms / status epilepticus
- Transient cerebral ischemia / stroke

Occasional
- Early death / lethality